THE MIR-483-5P AS A MARKER PREDICTING CHEMORESISTANCE IN EPITHELIAL OVARIAN CANCER KEYWORDS: MIR-483-5P, CHEMORESISTANCE, OVARIAN CANCER
Almost a quarter of a million women are diagnosed with ovarian cancer each year and more than half will die within five years of their diagnosis partly due to the difficult to cure together with develops resistance to the most common form of treatment, platinum-based chemotherapy. The aim of this study was to examine the relationship between miRNA expression and response to chemotherapy.
To conduct a genome-wide analysis of miRNA expression, epithelial ovarian cancer tissues from 7 resistance and 9 sensitive chemotherapy were analyzed using microarray chips. Candidate miRNAs were selected for validation by a quantitative reverse transcription-polymerase chain reaction.
Among 2,578 human mature microRNAs, high expression levels of miR-483-5p correlated with poor response to chemotherapy in patients with epithelial ovarian cancer. Our bioinformatics analyses show that miR-483-5p could promote ovarian cancer progression by modulating the gene expression of the cell cycle, cell proliferation, DNA damage, or apoptosis pathways.
Our findings suggest that miR-483-5p may be a predicting the response of chemotherapy or promising therapeutic candidate for the treatment of ovarian cancer. Further studies are required to characterize the mechanism involved in the chemoresistant process.