SQUAMOUS CELL CARCINOMA OVER CORNEA AFTER DIAGNOSIS OF NON-HODGKIN LYMPHOMA
The risk of second malignancy has increase in patients who diagnosed non-Hodgkin Lymphoma (NHL). We present a case of squamous cell carcinoma on ocular surface after diagnosis of NHL and complete remission for 12 years
An 81-year-old male presented with chronic irritation right eye for two months. The eye examination showed dark brown elevated mass 12 x 5 x 0.6 mm extended from corneal limbus, encroached temporal half of the right cornea. The lesion was not movable. He had been diagnosed diffuse large B-cell lymphoma and complete remission after having chemotherapy and radiation therapy in 2007. The ultrasound biomicroscopy showed no intraocular extension. The lymphnodes were all not palpable and other physical examinations revealed normal. "
The wide excision with cryotherapy and amniotic membrane graft was performed using no-touch technique. The histopathology diagnosed invasive squamous cell carcinoma with positive margins on nasal side. Mitomicin C 0.02% eye drop, qid, 1 wk on and 1 wk off, was applied postoperatively. The patient was followed up for more than two months with no recurrence seen.
Squamous cell carcinoma on ocular surface can develop as the second malignancy after diagnosed of non-Hodgkin lymphoma.